Biologic product device excipient guide

Medicine name
Company
Contains citrate
Contains latex
Other excipients
GuselkumabJanssen-CilagNN
  • Histidine
  • Histidine hydrochloride monohydrate
  • Polysorbate 80
  • Sucrose
IxekizumabEli LillyY

  • Sodium citrate dihydrate
  • Citric acid
N
  • Sodium chloride
  • Polysorbate 80
RizankizumabAbbvieNN
  • Sodium succinate hexahydrate
  • Succinic acid
  • Sorbitol
  • Polysorbate 20
SecukinumabNovartisNY

The removable cap of the pre-filled syringe contains a derivative of natural rubber latex

  • Trehalose dihydrate
  • Histidine
  • Histidine hydrochloride monohydrate
  • Methionine
  • Polysorbate 80
TildrakizumabSun PharmaNN
  • Histidine
  • Histidine hydrochloride monohydrate
  • Polysorbate 80
  • Sucrose
TocilizumabRocheNN
  • Histidine
  • Histidine hydrochloride
  • Arginine Arginine hydrochloride
  • Methionine
  • Polysorbate 80
UstekinumabJanssen-CilagNY

The needle cover (supplied with product) is manufactured using a dry natural rubber containing latex.

  • Histidine
  • Histidine hydrochloride monohydrate
  • Polysorbate 80
  • Sucrose
AbataceptBristol-Meyer SquibbNN
  • Sucrose
  • Poloxamer
  • Monophasic sodium phosphate
  • Dibasic sodium phosphate
AdalimumabAbbvie (Humira)

40mg/0.8mL, 20mg/0.4ml (pre-filled syringes and pens)

Y

  • Citric acid monohydrate
  • Sodium citrate dihydrate
N
  • Mannitol
  • Monobasic sodium phosphate dihydrate
  • Dibasic sodium phosphate dihydrate
  • Sodium chloride
  • Polysorbate 80
Abbvie (Humira)

20mg/0.2mL, 40mg/0.4mL, 80mg/0.8mL (pre-filled syringes and pens)

NN
  • Mannitol
  • Polysorbate 80
Sandoz (Hyrimoz)Y

  • Citric acid monohydrate
N
  • Adipic acid
  • Sodium chloride
  • Mannitol
  • Polysorbate 80
  • Hydrochloric acid
  • Sodium hydroxide
Amgen (Amgevita)NY

The needle cover of the pre-filled pen contains dry natural rubber (latex).

The needle cover of the pre-filled syringe does not contain latex.

  • Glacial acetic acid
  • Polysorbate 80
  • Sodium hydroxide sucrose
Samsung Bioepis (Hadlima)Y

  • Sodium citrate dihydrate
  • Citric acid monohydrate
N
  • L-histidine
  • L-histidine hydrochloride monohydrate
  • Sorbitol
  • Polysorbate 20
Fresenius Kabi (Idacio)Y

  • Sodium citrate dihydrate
  • Citric acid monohydrate
N
  • Monophasic sodium phosphate dihydrate
  • Dibasic sodium phosphate dihydrate
  • Mannitol
  • Sodium chloride
  • Polysorbate 80
  • Sodium hydroxide
Certolizumab pegolUCB PharmaNY

The needle shield for both the pre-filled pen and syringe contain epoxyprene, a natural derivative of latex

  • Sodium acetate
  • Sodium chloride
EtanerceptPfizer (Enbrel)NY

The needle cover for both the pre-filled syringe and auto-injector contain dry natural rubber (a derivative of latex).

The rubber closure of the diluent syringe also contains dry natural rubber.

Powder for injection

  • Mannitol
  • Trometamol
  • Sucrose

Pre-filled syringe and auto-injector

  • Sucrose
  • Sodium chloride
  • Arginine hydrochloride
  • Monophasic sodium phosphate
  • Dibasic sodium phosphate Phosphate dihydrate
Merck Sharpe and Dohme (Brenzys)NN
  • Sucrose
  • Sodium chloride
  • Sodium phosphate monobasic monohydrate
  • Sodium phosphate dibasic
GolimumabJanssen-CilagNY

The needle shield on both the pre-filled syringe and SmartJect injector pen are manufactured from a dry natural rubber containing latex.

  • Sorbitol
  • Histidine
  • Histidine hydrochloride monohydrate
  • Polysorbate 80
InfliximabJanssen-Cilag (Remicade)NN
  • Monobasic sodium phosphate monohydrate
  • Dibasic sodium phosphate dihydrate
  • Sucrose
  • Polysorbate 80
Samsung-Bioepsis (Renflexis)NN
  • Monobasic sodium phosphate monohydrate
  • Dibasic sodium phosphate dihydrate
  • Sucrose
  • Polysorbate 80
Pfizer (Inflectra)NN
  • Monobasic sodium phosphate monohydrate
  • Dibasic sodium phosphate dihydrate
  • Sucrose
  • Polysorbate 80
Celltrion (Remsima SC)NN
  • Acetic acid
  • Sodium acetate trihydrate
  • Sorbitol
  • Polysorbate 80
RituximabRoche (Mabthera)Y

  • Sodium citrate
N
  • Polysorbate 80
  • Sodium chloride
  • Sodium hydroxide and/or Hydrochloric acid
Sandoz (Riximyo)Y

  • Citric acid monohydrate
N
  • Sodium chloride
  • Polysorbate 80
  • Sodium hydroxide and/or Hydrochloric acid
Celltrion (Truxima)Y

  • Sodium citrate
N
  • Polysorbate 80
  • Sodium chloride
  • Sodium hydroxide and/or Hydrochloric acid
VedolizumabTakeda Pharmaceuticals

IV infusion

NN
  • Histidine
  • Histidine hydrochloride monohydrate
  • Arginine hydrochloride
  • Sucrose
  • Polysorbate 80

Pre-filled pen and syringe
Y

  • Citric acid monohydrate
  • Sodium citrate dihydrate
N
  • Histidine
  • Histidine hydrochloride monohydrate
  • Arginine hydrochloride
  • Polysorbate 80